The regioselective synthesis of 2,5- and 4,5-disubstituted thiazoles <i>via</i> the cyclization of 2-oxo-2-(amino)ethanedithioates with isocyanides
Krishna Ravi Singh, Chikkappaiahnayaka Santhosh, Toreshettahally R. Swaroop, Maralinganadoddi P. Sadashiva
Abstract
the base-induced cyclization of methyl-2-oxo-2-(amino)ethanedithioates with TosMIC and ethyl isocyanoacetate, respectively, with high yields. The regioisomeric products were confirmed based on X-ray diffraction studies. An advantage of the present method is the wide-ranging isocyanide reactivity compared to earlier protocols, while the catalyst-free nature and rapid reaction times are noteworthy features.
Topics & Concepts
ChemistryRegioselectivityCombinatorial chemistryStereochemistryIsocyanideOrganic chemistryCatalysisSynthesis of heterocyclic compoundsSulfur-Based Synthesis TechniquesSynthesis and Characterization of Heterocyclic Compounds