Utilization of Unsymmetric Diaryliodonium Salts in α‐Arylation of α‐Fluoroacetoacetamides
Mohd Khalid Zaheer, Narendra Kumar Vaishanv, Ruchir Kant, Kishor Mohanan
Abstract
The use of unsymmetric diaryliodonium salts as a versatile class of arylating agents has been demonstrated by developing a novel strategy to quickly access α-arylated α-fluoroacetoacetamides. The protocol provides a convenient metal-free method for the α-arylation of a diverse class of fluorinated acetoacetamides, and the products are obtained in good yields. The strategy, upon use of electron-deficient diaryliodonium salts as an arylating agent, provides α-fluoroacetamides through a spontaneous arylation/deacylation cascade.
Topics & Concepts
CascadeClass (philosophy)Combinatorial chemistryProtocol (science)Computer scienceDecompositionChemistryOrganic chemistryArtificial intelligenceMedicinePathologyChromatographyAlternative medicineFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions