MOrPH-PhD: An Integrated Phage Display Platform for the Discovery of Functional Genetically Encoded Peptide Macrocycles
Andrew E. Owens, Jacob A. Iannuzzelli, Yu Gu, Rudi Fasan
Abstract
: 550 nM). This work introduces and validates an efficient and general platform for the discovery and evolution of functional, conformationally constrained macrocyclic peptides useful for targeting proteins and protein-mediated interactions.
Topics & Concepts
Phage displayPeptideComputational biologyPeptide libraryProtein tagDrug discoveryCombinatorial chemistryChemistryBiotinylationSmall moleculeBiochemistryPeptide sequenceBiologyFusion proteinGeneRecombinant DNAChemical Synthesis and AnalysisBiochemical and Structural CharacterizationMonoclonal and Polyclonal Antibodies Research