Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs
Georg Schett, Iain B. McInnes, Markus F. Neurath
Abstract
The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders and their inefficacy in giant-cell arteritis and multiple sclerosis), providing a framework for reclassification.
Topics & Concepts
CytokineImmunologyMedicineMultiple sclerosisImmune systemTumor necrosis factor alphaGiant cell arteritisCognitive reframingNOD2DiseaseInnate immune systemVasculitisPathologyPsychologySocial psychologyInflammatory Bowel DiseaseSystemic Lupus Erythematosus ResearchAutoimmune and Inflammatory Disorders Research