High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy
Xiangqin Meng, Dandan Li, Lei Chen, Helen He, Qian Wang, Chaoyi Hong, Jiuyang He, Xingfa Gao, Yili Yang, Bing Jiang, Guohui Nie, Xiyun Yan, Lizeng Gao, Kelong Fan
Abstract
OH and deplete reduced glutathione, which induces apoptosis as well as ferroptosis of tumor cells. Consequently, it killed apoptosis-resistant tumor cells harboring KRAS mutation by inducing ferroptosis. The pyrite nanozyme also exhibited favorable tumor-specific cytotoxicity and biodegradability to ensure its biosafety. These results indicate that the high-performance pyrite nanozyme is an effective therapeutic reagent and may aid the development of nanozyme-based tumor catalytic therapy.
Topics & Concepts
ChemistryHydrogen peroxideHorseradish peroxidasePeroxidasePyriteCytotoxicityReactive oxygen speciesApoptosisGlutathioneBiochemistryEnzymeIn vitroMineralogyAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranosticsNanocluster Synthesis and Applications