Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis
Daphne S. Bakker, Marlot van der Wal, Lukas E. M. Heeb, Barbara Giovannone, Mindy Asamoah, Eveline M. Delemarre, Julia Drylewicz, Stefan Nierkens, Onur Boyman, Marjolein de Bruin‐Weller, Judith L. Thijs, Femke van Wijk
Abstract
T cells at week 4. No evidence of general T helper type cell skewing following a year of dupilumab treatment was found. In summary, dupilumab treatment rapidly and stably inhibited IL-4Rα, which was accompanied by a strong early functional immunological effect specifically on skin-homing T cells without affecting overall T helper type cell skewing in the long term.
Topics & Concepts
DupilumabAtopic dermatitisMedicineDermatologyTerm (time)ImmunologyPhysicsQuantum mechanicsDermatology and Skin DiseasesUrticaria and Related ConditionsAllergic Rhinitis and Sensitization