PorZ, an Essential Component of the Type IX Secretion System of <i>Porphyromonas gingivalis</i> , Delivers Anionic Lipopolysaccharide to the PorU Sortase for Transpeptidase Processing of T9SS Cargo Proteins
Mariusz Madej, Zuzanna Nowakowska, Mirosław Książęk, Anna M. Łasica, Danuta Mizgalska, Magdalena Nowak, Anna Jacuła, Monika Bzowska, Carsten Scavenius, Jan J. Enghild, Joseph Aduse‐Opoku, Michael A. Curtis, F. Xavier Gomis‐Rüth, Jan Potempa
Abstract
Bacteria have evolved multiple systems to transport effector proteins to their surface or into the surrounding milieu. These proteins have a wide range of functions, including attachment, motility, nutrient acquisition, and toxicity in the host. Porphyromonas gingivalis , the human pathogen responsible for severe gum diseases (periodontitis), uses a recently characterized type IX secretion system (T9SS) to translocate and anchor secreted virulence effectors to the cell surface.
Topics & Concepts
Porphyromonas gingivalisSortaseSecretionMannanBacterial outer membraneCell biologyChemistryBiochemistryPeriplasmic spaceLipid ABiologyLipopolysaccharideEscherichia coliBacteriaPolysaccharideGeneGeneticsBacterial proteinEndocrinologyStreptococcal Infections and TreatmentsOral microbiology and periodontitis researchBiochemical and Structural Characterization