Novel Mannich bases of ciprofloxacin with improved physicochemical properties, antibacterial, anticancer activities and caspase-3 mediated apoptosis
Islam M. Abdel-Rahman, Muhamad Mustafa, Soad A. Mohamed, Ramadan Yahia, Mohamed Abdel‐Aziz, Gamal El‐Din A. Abuo‐Rahma, Alaa M. Hayallah
Topics & Concepts
ChemistryCiprofloxacinStaphylococcus aureusAntibacterial activityApoptosisEscherichia coliMannich baseIC50Pseudomonas aeruginosaStereochemistryPotencyCytotoxicityAntibioticsBacteriaIn vitroBiochemistryOrganic chemistryBiologyGeneGeneticsCancer therapeutics and mechanismsSynthesis and biological activityBioactive Compounds and Antitumor Agents