Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits
Luciano Gastón Morosi, Anabela M. Cutine, Alejandro J. Cagnoni, Montana N Manselle Cocco, Diego O. Croci, Joaquín P. Merlo, Rosa María Morales, María May, Juan M. Pérez‐Sáez, María Romina Girotti, Santiago P. Méndez‐Huergo, Betiana Pucci, Aníbal H. Gil, Sergio P. Huernos, Guillermo Docena, Alicia M. Sambuelli, Marta A. Toscano, Gabriel A. Rabinovich, Karina V. Mariño
Abstract
mice showed attenuated inflammation. These effects were associated with intrinsic T cell glycosylation. Thus, Gal1 and its glycosylated ligands act to preserve intestinal homeostasis by recalibrating T cell immunity.
Topics & Concepts
InflammationGlycosylationLectinImmunologyBiologyCell biologyBiochemistryGalectins and Cancer BiologyGlycosylation and Glycoproteins ResearchImmune Cell Function and Interaction