Occupational infection to Brucella abortus B19 vaccine despite antimicrobial prophylaxis
Alexandre Sampaio Moura, Letícia Mattos Menezes, Marcelle Amaral de Matos, Cynthya Magalhães Costa, Bruna Arantes Borges
Abstract
The authors report the case of a veterinarian who acquired brucellosis infection by accidental exposure to Brucella abortus vaccine (BRUCEL-VET B19) while performing animal vaccination. Antibiotic prophylaxis with doxycycline and rifampin for six weeks was indicated, but rifampin was discontinued after 10 days due to gastrointestinal intolerance. Despite prophylaxis, the patient seroconverted after 30 days, but was asymptomatic and did not require additional antibiotic therapy. Post-exposure prophylaxis of Brucella is not free from side effects and asymptomatic seroconversion can occur despite prophylaxis.
Topics & Concepts
MedicineDoxycyclineBrucellosisBrucellaAsymptomaticSeroconversionVaccinationAntibioticsAntimicrobialAntibiotic prophylaxisImmunologyInternal medicineMicrobiologyAntibodyBiologyBrucella: diagnosis, epidemiology, treatmentCeliac Disease Research and ManagementBurkholderia infections and melioidosis