A Greener Pathway to Enantiopurity: Mechanochemical Deracemization through Abrasive Grinding
Chrystal Lopes, Yohann Cartigny, Clément Brandel, Valérie Dupray, Carole Body, Oleksii Shemchuk, Tom Leyssens
Abstract
We report the first case of mechanochemical deracemization by using liquid-assisted abrasive grinding. The target molecule is a precursor of Paclobutrazol, an important fungicide and plant growth inhibitor. Using mechanochemical deracemization, we are even able to transform a 10 % ee scalemic mixture of this latter in an enantioenriched product of 97 % ee in a couple of hours. This is substantially shorter compared to solution-based deracemization methodologies. The present paper thus introduces an efficient and greener process to enantiopure material.
Topics & Concepts
GrindingPaclobutrazolAbrasiveEnantiopure drugFungicideChemistryMaterials scienceMathematicsChemical engineeringOrganic chemistryEngineeringBotanyMetallurgyBiologyCatalysisEnantioselective synthesisChemical synthesis and alkaloidsAnalytical Chemistry and ChromatographyForce Microscopy Techniques and Applications