Two-dimensional Imaging of a Model Pharmaceutical Dosage Tablet Using a Scanning Vibrational Circular Dichroism System
Hisako Sato, Sumio Aisawa, Honoka Ida, Masaru Shimizu, Keisuke Watanabe, Jun Koshoubu, Jun Yoshida, Izuru Kawamura
Abstract
Abstract A vibrational circular dichroism (VCD) system with a quantum-cascade laser was used to obtain a two-dimensional image of VCD signals on a pharmaceutical tablet. A KBr disc of a model dosage form was prepared using tartaric acid and phenylalanine as chiral multi-reagents and layered double hydroxides as excipients. VCD spectra were obtained in the range 1500–1700 cm−1 at a 1 mm i.d. spatial resolution. The results demonstrated the utility of the proposed system in quality control during drug manufacturing.
Topics & Concepts
ChemistryTartaric acidVibrational circular dichroismCircular dichroismCascadeReagentResolution (logic)Quantum cascade laserAnalytical Chemistry (journal)OpticsStereochemistryChromatographyOrganic chemistryPhysicsCitric acidArtificial intelligenceComputer scienceMolecular spectroscopy and chiralitySpectroscopy and Quantum Chemical StudiesPhotoreceptor and optogenetics research