Active ester-based peptide bond formation and its application in peptide synthesis
Jinhua Yang, Huanan Huang, Junfeng Zhao
Abstract
Active ester method is an efficient strategy to address the notorious racemization/epimerization issue of peptide bond formation. Herein, the pros and cons of using active esters for peptide synthesis were systematically summarized and analyzed.
Topics & Concepts
ChemistryRacemizationEpimerPeptidePeptide synthesisPeptide bondCombinatorial chemistryStereochemistryBiochemistryChemical Synthesis and AnalysisClick Chemistry and ApplicationsMicrobial Natural Products and Biosynthesis