Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma
Ibrahim H. Eissa, M.K. Ibrahim, Ahmed M. Metwaly, Amany Belal, Ahmed B. M. Mehany, Alsayed A. Abdelhady, Mostafa A. Elhendawy, Mohamed M. Radwan, Mahmoud A. ElSohly, Hazem A. Mahdy
Topics & Concepts
SorafenibChemistryIn vivoDocking (animal)IC50Protein Data Bank (RCSB PDB)ApoptosisHepatocellular carcinomaDoxorubicinGrowth inhibitionIn vitroCell culturePharmacologyCancer researchStereochemistryBiochemistryInternal medicineBiologyChemotherapyMedicineGeneticsNursingBiotechnologyQuinazolinone synthesis and applicationsCancer Mechanisms and TherapySynthesis and biological activity