Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort
Bonnie Ronish, David Couper, Igor Barjaktarević, Christopher B. Cooper, Richard E. Kanner, C.S. Pirozzi, Victor Kim, J. Michael Wells, MeiLan K. Han, Prescott G. Woodruff, Victor E. Ortega, Stephen P. Peters, Eric A. Hoffman, Russell G. Buhr, Brett A. Dolezal, Donald P. Tashkin, Theodore G. Liou, Lori A. Bateman, Joyce Schroeder, Fernando J. Martínez, R. Graham Barr, Nadia N. Hansel, Alejandro P. Comellas, Stephen I. Rennard, Mehrdad Arjomandi, Robert Paine
Abstract
BACKGROUND: ]) as an additional tool for characterizing pathophysiology in COPD. OBJECTIVE: helps predict clinical and radiographic abnormalities in COPD. STUDY DESIGN AND METHODS: ) and both clinical markers and computed tomography (CT) findings of smoking-related lung disease. RESULTS: or forced vital capacity (FVC). INTERPRETATION: helps link the anatomic pathology and deranged physiology of COPD.