How hydrophilic group affects drug–protein binding modes: Differences in interaction between sirtuins inhibitors Tenovin-1/Tenovin-6 and human serum albumin
Na Gan, Qiaomei Sun, Zili Suo, Shuangshuang Zhang, Ludan Zhao, Hongzhao Xiang, Wenjing Wang, Zhiqiang Li, Xiaoxiang Liao, Hui Li
Topics & Concepts
ChemistryHuman serum albuminCircular dichroismHydrophobic effectDifferential scanning calorimetryHydrogen bondQuenching (fluorescence)StereochemistryBiophysicsFluorescenceBiochemistryMoleculeOrganic chemistryBiologyPhysicsQuantum mechanicsThermodynamicsProtein Interaction Studies and Fluorescence AnalysisAnalytical Chemistry and ChromatographyMolecular spectroscopy and chirality