Amyloid-β precursor protein processing and oxidative stress are altered in human iPSC-derived neuron and astrocyte co-cultures carrying presenillin-1 gene mutations following spontaneous differentiation
Richard J. Elsworthy, Marianne C. King, Alastair I. Grainger, Emily Fisher, James A Crowe, Sarah Alqattan, Adele Ludlam, Eric J. Hill, Sarah Aldred
Topics & Concepts
BiologyAstrocyteMutationPSEN1PresenilinMolecular biologyAmyloid precursor proteinOxidative stressCell biologyAlzheimer's diseaseBiochemistryGeneEndocrinologyInternal medicineCentral nervous systemDiseaseMedicineAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis ResearchPrion Diseases and Protein Misfolding