Aldehyde dehydrogenase 2 regulates autophagy via the Akt-mTOR pathway to mitigate renal ischemia-reperfusion injury in hypothermic machine perfusion
Danni Lin, Tao Xiang, Qiangmin Qiu, Junto Leung, Junjie Xu, Wei Zhou, Qianchao Hu, Jianan Lan, Zhongzhong Liu, Zibiao Zhong, Yanfeng Wang, Qifa Ye
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayReperfusion injuryMachine perfusionAldehyde dehydrogenasePerfusionIschemiaMedicineProtein kinase BChemistryPharmacologyBiochemistryEnzymeApoptosisInternal medicineTransplantationLiver transplantationAlcohol Consumption and Health EffectsOrgan Transplantation Techniques and OutcomesHeme Oxygenase-1 and Carbon Monoxide