NIR-II responsive PEGylated nickel nanoclusters for photothermal enhanced chemodynamic synergistic oncotherapy
Yong Qian, Shuai Zhang, Jinglu Zou, Xingyu Wang, Xiangfu Meng, Hongji Liu, Yefeng Lin, Qianwang Chen, Lei Sun, Wenchu Lin, Hui Wang
Abstract
we developed a novel synthetic strategy to tune crystallinity and shape of PUNNC for enhanced NIR-II responsive photothermal conversion efficiency and accelerated acid-induced dissolution for improved ·OH generation. Such 9T-PUNNC enable a combined chemodynamic-photothermal treatment to provide superior therapeutic efficacy due to their highly synergistic effect.
Topics & Concepts
Photothermal therapyBiocompatibilityNanoclustersChemistryCrystallinityPolyethylene glycolIrradiationPhotothermal effectMaterials scienceNanotechnologyBiochemistryCrystallographyNuclear physicsPhysicsOrganic chemistryAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranosticsNanocluster Synthesis and Applications