The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII
Alessandro Bonardi, Silvia Bua, Jacob Combs, Carrie L. Lomelino, Jacob T. Andring, Sameh M. Osman, Alessandra Toti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Robert McKenna, Alessio Nocentini, Claudiu T. Supuran
Abstract
) conditions demonstrating relevant anti-proliferative effects.
Topics & Concepts
Gene isoformCarbonic anhydraseEnzymeChemistryProstate cancerActive siteIn vitroMode of actionBiochemistryCancer researchCancerBiologyGeneGeneticsEnzyme function and inhibitionSynthesis and Catalytic ReactionsChemical Reactions and Mechanisms