Synthesis, Antiproliferative Effect, and Topoisomerase II Inhibitory Activity of 3-Methyl-2-phenyl-1<i>H</i>-indoles
Nace Zidar, Daniela Secci, Tihomir Tomašič, Lucíja Peterlin Mašič, D. Kikelj, Daniele Passarella, Aída Nelly García Argáez, Mariafrancesca Hyeraci, Lisa Dalla Via
Abstract
-indole as a promising scaffold for further optimization of compounds with potent antiproliferative and antitopoisomerase II activities.
Topics & Concepts
HeLaTopoisomeraseApoptosisStereochemistryChemistryCell cultureCell growthIndole testInhibitory postsynaptic potentialBiological activityBiochemistryDNACellIn vitroBiologyNeuroscienceGeneticsCancer therapeutics and mechanismsBioactive Compounds and Antitumor AgentsSynthesis and bioactivity of alkaloids