<i>IRGM/Irgm1</i> facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: <i>Irgm1</i><sup>+/-</sup> mice display increases atherosclerotic plaque stability
Shaohong Fang, Song Yung Sun, Hengxuan Cai, Xiaoyi Zou, Shanjie Wang, Xinran Hao, Xin Wan, Jiangtian Tian, Zhaoying Li, Zhongze He, Wei Huang, Chenchen Liang, Zhenming Zhang, Liming Yang, Jinwei Tian, Bo Yu, Bo Sun
Abstract
may represent a new treatment strategy for the prevention and treatment of acute cardiovascular deaths caused by PR.
Topics & Concepts
AutophagyApoptosisVulnerable plaqueCell biologyMacrophageWestern blotFibrous capBiologyProgrammed cell deathSignal transductionPathologyMolecular biologyMedicineCancer researchChemistryIn vitroBiochemistryGeneCell Adhesion Molecules ResearchImmune cells in cancerAtherosclerosis and Cardiovascular Diseases