A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo
Ástrós Skúladóttir, Gyða Björnsdóttir, Muhammad Sulaman Nawaz, Hannes Petersen, Sölvi Rögnvaldsson, Kristjan H. S. Moore, Pall I. Olafsson, Sigurður H. Magnússon, Anna Bjornsdottir, Ólafur Sveinsson, Gudrun R. Sigurdardottir, Saedís Saevarsdóttir, Erna V. Ivarsdottir, Lilja Stefánsdóttir, Bjarni Gunnarsson, Joseph B. Muhlestein, Kirk U. Knowlton, David A. Jones, Lincoln Nadauld, Annette M. Hartmann, Dan Rujescu, Michael Strupp, G. Bragi Walters, Thorgeir E. Thorgeirsson, Ingileif Jónsdóttir, Hilma Hólm, Guðmar Þorleifsson, Daníel F. Guðbjartsson, Patrick Sulem, Hreinn Stefánsson, Kāri Stefánsson
Abstract
= 894,541), we uncovered an association with six common sequence variants in individuals of European ancestry, including missense variants in ZNF91, OTOG, OTOGL, and TECTA, and a cis-eQTL for ARMC9. The association of variants in ZNF91, OTOGL, and OTOP1 was driven by an association with benign paroxysmal positional vertigo. Using previous reports of sequence variants associating with age-related hearing impairment and motion sickness, we found eight additional variants that associate with vertigo. Although disorders of the auditory and the vestibular system may co-occur, none of the six genome-wide significant vertigo variants were associated with hearing loss and only one was associated with age-related hearing impairment. Our results uncovered sequence variants associating with vertigo in a genome-wide association study and implicated genes with known roles in inner ear development, maintenance, and disease.