Evaluating glioblastoma tumour sphere growth and migration in interaction with astrocytes using 3D collagen-hyaluronic acid hydrogels
Yixiao Cui, Paul Lee, Jesse J. Reardon, Anna Wang, S E Lynch, José Javier Otero, Gina M. Sizemore, Jessica O. Winter
Abstract
Glioblastoma cells co-cultured with astrocytes in col-HA hydrogels exhibit changes in migration patterns. 3D in vitro models using ECM mimetic materials can be used to analyze glioma-astrocyte crosstalk.
Topics & Concepts
Self-healing hydrogelsHyaluronic acidGlioblastomaCrosstalkAstrocyteGliomaIn vitroSpheroidMaterials scienceCell biologyBiophysicsBiomedical engineeringCancer researchChemistryNeuroscienceBiochemistryBiologyMedicineAnatomyPolymer chemistryCentral nervous systemEngineeringElectronic engineering3D Printing in Biomedical ResearchCellular Mechanics and InteractionsCancer Cells and Metastasis