Litcius/Paper detail

MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

Vivek Verma, Nazli Jafarzadeh, Shannon K. Boi, Subhadip Kundu, Zhinuo Jiang, Yiping Fan, J. Alejandro López, Rahul Nandre, Peng Zeng, Fatmah Alolaqi, Shamim Ahmad, Pankaj Gaur, Simon T. Barry, Viia Valge-Archer, Paul D. Smith, Jacques Banchereau, Mikayel Mkrtichyan, Ben Youngblood, Paulo C. Rodrı́guez, Seema Gupta, Samir N. Khleif

2020Nature Immunology180 citationsDOIOpen Access PDF

Topics & Concepts

CD8Cytotoxic T cellCancer researchCell biologyStem cellT cellBiologyImmunologyChemistryImmune systemIn vitroBiochemistryCAR-T cell therapy researchT-cell and B-cell ImmunologySingle-cell and spatial transcriptomics