MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects
Vivek Verma, Nazli Jafarzadeh, Shannon K. Boi, Subhadip Kundu, Zhinuo Jiang, Yiping Fan, J. Alejandro López, Rahul Nandre, Peng Zeng, Fatmah Alolaqi, Shamim Ahmad, Pankaj Gaur, Simon T. Barry, Viia Valge-Archer, Paul D. Smith, Jacques Banchereau, Mikayel Mkrtichyan, Ben Youngblood, Paulo C. Rodrı́guez, Seema Gupta, Samir N. Khleif
Topics & Concepts
CD8Cytotoxic T cellCancer researchCell biologyStem cellT cellBiologyImmunologyChemistryImmune systemIn vitroBiochemistryCAR-T cell therapy researchT-cell and B-cell ImmunologySingle-cell and spatial transcriptomics