Lymphatic Type 1 Interferon Responses Are Critical for Control of Systemic Reovirus Dissemination
Matthew B. Phillips, Marcelle Dina Zita, Morgan A. Howells, Tiffany Weinkopff, Karl W. Boehme
Abstract
technology enabled dissemination of the IFN-1-sensitive σ1s-deficient reovirus. Together, our results indicate that IFN-1 responses in lymphatics are critical for controlling reovirus systemic spread.
Topics & Concepts
BiologyLymphatic systemInterferonVirologyViral replicationInterferon type IVirusReoviridaeImmunologyRotavirusErythrocyte Function and PathophysiologyPhagocytosis and Immune RegulationViral gastroenteritis research and epidemiology