Myoepithelial Carcinoma of Soft Tissue With an <i>EWSR1-KLF15</i> Gene Fusion in an Infant
Sandor Bodis, Sabine Kroiss, Joëlle Tchinda, Christine Fritz, Ulrich Wagner, Peter K. Bode
Abstract
Overall, neonatal cancer is uncommon. Because of its rarity and heterogeneity, diagnosis can be challenging. We report a unique case of a myoepithelial carcinoma in a 7 week old girl. Molecular diagnostic workup revealed a EWSR1-KLF15 gene fusion which was previously described in only six cases of myoepithelial tumors so far. All cases occurred in children and adolescents. To our knowledge, this is the first report of a congenital EWSR1-KLF15 fusion positive myoepithelial tumor in an infant.
Topics & Concepts
Myoepithelial cellMyoepitheliomaFusion genePathologyCarcinomaMedicineBiologyGeneGeneticsImmunohistochemistryTumors and Oncological CasesVascular Malformations and HemangiomasSoft tissue tumor case studies