Prospective Evaluation of <sup>18</sup>F-DCFPyL PET/CT in Detection of High-Risk Localized Prostate Cancer: Comparison With mpMRI
Sonia Gaur, Esther Mena, Stephanie A. Harmon, Maria Liza Lindenberg, Stephen Adler, Anita Ton, Joanna H. Shih, Sherif Mehralivand, Maria J. Merino, Bradford J. Wood, Peter A. Pinto, Ronnie C. Mease, Martin G. Pomper, Peter L. Choyke, Barış Türkbey
Abstract
F-DCFPyL PET/CT is highly sensitive in detecting intraprostatic tumors and can detect tumors missed on mpMRI. Measured uptake is significantly higher in tumor tissue, and PSMA-derived tumor burden is associated with severity of disease.
Topics & Concepts
MedicineProstate cancerHistopathologyNuclear medicineProspective cohort studyBiopsyProstatePET-CTStandardized uptake valueCancerRadiologyPositron emission tomographyPathologyInternal medicineProstate Cancer Treatment and ResearchProstate Cancer Diagnosis and TreatmentUrologic and reproductive health conditions