Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1
Chengxin Zhang, Wei Zheng, Xiaoqiang Huang, Eric W. Bell, Xiaogen Zhou, Yang Zhang
Abstract
coronavirus compared with 2019-nCoV, suggesting the pangolin as a missing link in the transmission of 2019-nCoV from bats to human.
Topics & Concepts
Spike (software development)GenomeMetagenomicsComputational biologyBiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Similarity (geometry)PneumoniaCoronavirus disease 2019 (COVID-19)CoronavirusTransmission (telecommunications)Sequence (biology)Host (biology)2019-20 coronavirus outbreakGeneticsVirologyGeneComputer scienceMedicineArtificial intelligencePathologyOutbreakSoftware engineeringInfectious disease (medical specialty)DiseaseInternal medicineTelecommunicationsImage (mathematics)SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesBacteriophages and microbial interactions