1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation
Mario Lauterbach, Víctor Saavedra, Matthew Mangan, Anke Penno, Christoph Thiele, Eicke Latz, Lars Kuerschner
Abstract
picCy3: azido-picolylcyanine 3; NLRP3: NOD-like receptor pyrin domain containing protein 3; P4HB: prolyl 4-hydroxylase subunit beta; PINK1: PTEN induced putative kinase 1; PYCARD/ASC: PYD and CARD domain containing; SPTLC1: serine palmitoyltransferase long chain base subunit 1; SQSTM1: sequestosome 1; TLC: thin layer chromatography.
Topics & Concepts
AutophagyInflammasomeAutophagosomeCell biologyBiologyLysosomeMitophagyInflammationInnate immune systemBiochemistryImmune systemImmunologyApoptosisEnzymeInflammasome and immune disordersAutophagy in Disease and TherapySphingolipid Metabolism and Signaling