Synthesis of 1<i>H</i>-indazoles by an electrochemical radical C<sub>sp<sup>2</sup></sub>–H/N–H cyclization of arylhydrazones
Hao Wan, Dongting Li, Huadan Xia, Liwen Yang, Hesham Alhumade, Hong Yi, Aiwen Lei
Abstract
-indazole derivatives in moderate to good yields. HFIP was not only employed as a solvent or the proton donor, but also can promote the formation of N free radicals. This synthetic methodology is operationally simple, and less expensive electrodes would be suitable for this chemistry.
Topics & Concepts
IndazoleElectrochemistryChemistryRadicalSolventRadical cyclizationCombinatorial chemistryMedicinal chemistryOrganic chemistryElectrodePhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques