A selective and mild electrochemical defluorinative carboxylation for late-stage C(sp<sup>3</sup>)–F bond functionalization
Subhojit Mondal, Soumik Sarkar, Jason W. Wang, Michael Meanwell
Abstract
We report a protocol for the electrochemical defluorinative carboxylation of trifluoromethyl groups for accessing their highly valuable α,α-difluorocarboxylic acid analogues.
Topics & Concepts
CarboxylationSurface modificationElectrochemistryTrifluoromethylChemistryTriple bondCombinatorial chemistryMedicinal chemistryOrganic chemistryDouble bondElectrodeCatalysisPhysical chemistryAlkylFluorine in Organic ChemistryCarbon dioxide utilization in catalysisCO2 Reduction Techniques and Catalysts