The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker
Xuewen Tan, Haifeng Jiang, Yilong Fang, Dafei Han, Ya-Wei Guo, Xinming Wang, Xun Gong, Wenming Hong, Jiajie Tu, Wei Wei
Abstract
Glioma is a malignant brain tumor with a generally poor prognosis. Dysregulation of a long non-coding RNA, GAS5, has been detected in numerous cancers, including glioma. Previous studies have suggested that GAS5 plays a significant functional role in glioma, affecting proliferation, metastasis, invasion, and apoptosis. In this review, we describe the roles and mechanisms of GAS5 in glioma. GAS5 may be a biomarker for diagnosis and prognosis, and even a potential target for glioma treatment, and therefore warrants further investigation.
Topics & Concepts
GAS5GliomaLong non-coding RNAmicroRNABiomarkerCancer researchMedicineBiologyRNAGeneGeneticsCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA regulation and disease