Enhanced permeability and retention (EPR) effect: Advances in nanomedicine for improved tumor targeting
Mohammad Sameer Khan, Taha Alqahtani, Humood Al Shmrany, Garima Gupta, Khang Wen Goh, Amirhossein Sahebkar, Prashant Kesharwani
Topics & Concepts
NanomedicineTumor microenvironmentCancer researchMedicineDrug deliveryStromal cellVascular permeabilityLimitingLymphatic systemCancerIntegrinNanocarriersInterstitial fluidDrug carrierCirculating tumor cellTherapeutic approachDoxorubicinCrosstalkChemistryBone marrowDrugRadiation therapyClinical PracticeCancer therapyTargeted drug deliveryPharmacologyIn vivoEndotheliumAngiogenesisPermeability (electromagnetism)Cancer treatmentPreclinical researchTumor progressionImmune systemTumor cellsBlood vesselBiomedical engineeringPersonalized medicineImmunotherapyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsRadiation Therapy and Dosimetry