cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
Hong Yien Tan, Yean K. Yong, Yuan Chao Xue, Huitao Liu, Tomomi Furihata, Esaki M. Shankar, Chen Seng Ng
Abstract
. cGAS/DDX41-STING-signaling is amplified in bystander cells through inter-neuronal gap junctions. Our results highlight the importance of a common DNA-sensing pathway between SOD1 and TDP-43 in influencing the progression of ALS.
Topics & Concepts
IRF3NeuroinflammationBystander effectCell biologySOD1InterferonBiologyMitochondrionCytosolChemistryImmunologyInnate immune systemImmune systemInflammationGeneGeneticsBiochemistryEnzymeMutantAmyotrophic Lateral Sclerosis Researchinterferon and immune responsesRNA Research and Splicing