Oligomannose <i>N</i> -Glycans 3D Architecture and Its Response to the FcγRIIIa Structural Landscape
Carl A. Fogarty, Elisa Fadda
Abstract
-glycans into structures not populated in the unlinked forms in solution. Ultimately, the highly populated conformations of the Man5 linked glycans support experimental evidence of high levels of hybrid complex forms at N45 and show a specific presentation of the arms at N162, which may be involved in mediating binding affinity to the IgG1 Fc.
Topics & Concepts
GlycanAntibody-dependent cell-mediated cytotoxicityGlycosylationChemistryGalectinMolecular dynamicsGlycoproteinBiochemistryCytotoxicityIn vitroComputational chemistryGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisMonoclonal and Polyclonal Antibodies Research