Comparative analysis of CRISPR off-target discovery tools following ex vivo editing of CD34+ hematopoietic stem and progenitor cells
M. Kyle Cromer, Kiran R. Majeti, Garrett R. Rettig, Karthik Murugan, Gavin Kurgan, Nicole M. Bode, Jessica P. Hampton, Christopher A. Vakulskas, Mark A. Behlke, Matthew H. Porteus
Topics & Concepts
Ex vivoBiologyHaematopoiesisProgenitor cellStem cellCRISPRCD34Genome editingProgenitorCell biologyIn vivoGeneticsGeneCRISPR and Genetic EngineeringInnovation and Socioeconomic DevelopmentCAR-T cell therapy research