FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation
Xinyi Yang, Xiaying Zhao, Yuqi Zhu, Jingna Xun, Wen Qin, Hanyu Pan, Jin‐Long Yang, Jing Wang, Zhimin Liang, Xiaoting Shen, Liang Yue, Qinru Lin, Huitong Liang, Min Li, Jun Chen, Shibo Jiang, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu
Abstract
T lymphocyte model, and detected differences in hnRNP U expression levels in samples from patients treated with antiretroviral therapy (ART) and healthy people, which further suggests that the FBXO34/hnRNP U axis is a new pathway involved in HIV-1 latency. These results provide mechanistic insights into the critical role of ubiquitination and hnRNP U in HIV-1 latency. This novel FBXO34/hnRNP U axis in HIV transcription may be directly targeted to control HIV reservoirs in patients in the future.
Topics & Concepts
Heterogeneous nuclear ribonucleoproteinRibonucleoproteinVirus latencyUbiquitin ligaseBiologyUbiquitinReverse transcriptaseViral replicationVirologyCell biologyGeneticsCell cultureRNAGeneHIV Research and TreatmentCRISPR and Genetic EngineeringHIV/AIDS drug development and treatment