Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition
Yuan Yuan, Guowen Jia, Chao Wu, Wei Wang, Lin Cheng, Qian Li, Ziyan Li, Kaidong Luo, Shengyong Yang, Wei Yan, Zhaoming Su, Zhenhua Shao
Topics & Concepts
Sphingosine-1-phosphate receptorBiologyHeterotrimeric G proteinReceptorG protein-coupled receptorS1PR1Cell biologySphingosineSignal transductionSphingosine-1-phosphateBiochemistryG proteinVEGF receptorsCancer researchVascular endothelial growth factorVascular endothelial growth factor ASphingolipid Metabolism and SignalingLipid Membrane Structure and BehaviorCellular transport and secretion