Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives
Jelena Rupar, Vladimir Dobričić, Jelena Grahovac, Siniša Radulović, Žiga Skok, Janez Ilaš, Mara Aleksić, Jasmina Brborić, Olivera Čudina
Abstract
Compounds <bold>6</bold>, <bold>7</bold>, <bold>8</bold> and <bold>9</bold> exhibit lower or similar IC<sub>50</sub> values compared to amsacrine and showed a lack of toxicity towards unstimulated normal human leucocytes.
Topics & Concepts
ChemistryAmino acidCombinatorial chemistryBiochemistryPharmacologyBiologyCancer therapeutics and mechanismsBioactive Compounds and Antitumor AgentsSynthesis and biological activity