Elucidating the mechanism and origin of diastereoselectivity in scandium-catalyzed β-C(sp<sup>3</sup>)–H activation and transformation of an aliphatic aldimine
Yiran Zhang, Yang Wang
Abstract
The mechanism and origin of regio- and diastereoselectivity in the reaction of divergent [3 + 2] annulation of aliphatic aldimines with alkenes by scandium-catalyzed β-C(sp 3 )–H activation have been revealed in detail using DFT calculations.
Topics & Concepts
AldimineChemistryScandiumCatalysisAnnulationReaction mechanismMechanism (biology)Transformation (genetics)StereochemistryMedicinal chemistryComputational chemistryOrganic chemistryEpistemologyGenePhilosophyBiochemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions