Ruthenium-Catalyzed Selectively Oxidative C–H Alkenylation of <i>N</i>-Acylated Aryl Sulfonamides by Using Molecular Oxygen as an Oxidant
Xueyuan Li, Xiao Hu, Zijie Liu, Jingshu Yang, Bo Mei, Yi Dong, Gang Liu
Abstract
aryl C-H alkenylation/annulation to afford five-membered sultam by using of molecular oxygen as an oxidant is reported in this article. Compared to the previous transition-metal-catalyzed C-H alkenylation of aryl sulfonamides, no excess metal salt oxidant was required in this method. A wide sulfonamide substrates scope and good regioselectivity and site-selectivity make this Ru-catalyzed method more attractive. Importantly, this method can not only be used to effectively prepare the biologically active five-membered sultam molecules but also be efficiently applied to the late-stage modification of sulfonamide drugs.
Topics & Concepts
SulfonamideArylRutheniumChemistryRegioselectivityCatalysisCombinatorial chemistryAnnulationOxidative phosphorylationMolecular oxygenOrganic chemistryAlkylBiochemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions