Identification of the key DNA damage response genes for predicting immunotherapy and chemotherapy efficacy in lung adenocarcinoma based on bulk, single-cell RNA sequencing, and spatial transcriptomics
Shijie Sun, Kai Wang, Deyu Guo, Haotian Zheng, Yong Liu, Hongchang Shen, Jiajun Du
Topics & Concepts
TranscriptomeImmunotherapyCisplatinChemotherapyPaclitaxelLung cancerCancer researchBiologyAdenocarcinomaDrug resistanceDocetaxelDNA repairGeneCancerImmune systemOncologyMedicineImmunologyGene expressionGeneticsFerroptosis and cancer prognosisCancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomics