Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1,2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors
Wenbin Jin, Chen Xu, Qipeng Cheung, Wei Gao, Ping Zeng, Jun Liu, Edward Wai‐Chi Chan, Yun‐Chung Leung, Tak Hang Chan, Kwok‐Yin Wong, Sheng Chen, Kin‐Fai Chan
Topics & Concepts
MeropenemChemistryEbselenCytotoxicityBioisostereMoietyIC50In vitroPharmacologyEffluxStereochemistryCombinatorial chemistryBiochemistryEnzymeAntibioticsChemical synthesisAntibiotic resistanceBiologyGlutathione peroxidaseGlutathioneAntibiotic Resistance in BacteriaPhenothiazines and Benzothiazines Synthesis and ActivitiesCancer therapeutics and mechanisms