Prognostic Significance of the angiopoietin-2 for Early Prediction of Septic Shock in Severe Sepsis Patients
Luu Thi Thanh Duyen, Bui Van Manh, Trần Thị Phương Thảo, Le Van Khanh, Bui Ngoc Linh Trang, Truong-Giang Ngo, Hà Văn Quang, Nguyen Thanh Viet, Ngo Thu Hang, Cấn Văn Mão, Nguyễn Lĩnh Toàn, Hoang Văn Tong
Abstract
Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis. Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA. Results: Angiopoietin-2 levels elevated according to the severity of sepsis progression. Angiopoietin-2 levels were correlated with mean arterial pressure and platelets counts, total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778). Conclusion: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.