<scp>Iodine‐DMSO</scp> catalyzed chemoselective oxidative aromatization and deallylation, nondeallylation of aryl allyl ether of tetrahydro‐<i>β</i>‐carboline
Sunil Gaikwad, Milind V. Gaikwad, Pradeep D. Lokhande
Abstract
Abstract We have developed a simple method for the chemoselective aromatization of tetrahydro‐ β ‐carboline with selective nondeallylation O ‐allyl groups in the presence of iodine (100 mol %) in dimethyl sulfoxide/H 2 O 2 . A convergent approach toward the oxidative aromatization with selective deallylation (deprotection) of O ‐allyl‐tetrahydro‐ β ‐carboline using iodine in dimethyl sulfoxide/HCl has been described. The present protocol contains cheap catalyst, easy work up, normal reaction conditions, and high selectivity.
Topics & Concepts
AromatizationChemistryCatalysisIodineDimethyl sulfoxideSelectivityArylOxidative phosphorylationSulfoxideOrganic chemistryEtherMedicinal chemistryAlkylBiochemistryChemical Synthesis and ReactionsSynthesis of Indole DerivativesMulticomponent Synthesis of Heterocycles