Radical Multicomponent Alkyl Alkynylation of Propellane via Synergistic Photoredox and Copper Catalysis
Jie Shi, Qiao-Lin Xu, Yu‐Qing Ni, Lin Li, Fei Pan
Abstract
butyl groups, and internal alkynes that can impact key physicochemical properties on drug candidates. Herein, we describe a novel and efficient reaction to synthesize alkyl-alkynyl-substituted BCP derivatives by synergistic photoredox and copper catalysis at room temperature. The mild reaction conditions, simple protocol, broad functional group tolerance, and high efficiency of this procedure make it a valuable strategy for accessing alkynyl-substituted BCPs.
Topics & Concepts
ChemistryAlkylPropellaneAlkynylationFunctional groupCatalysisArylCombinatorial chemistryPhotoredox catalysisCopperReaction conditionsBicyclic moleculeOrganic chemistryPhotocatalysisPolymerRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques