Tubulin-based dual-target compounds and protein degraders for cancer therapy—An updated review (2021-present)
Shijia Li, Zhouyan Liu, Tong Li, Ziwei Tang, Yanyan Feng, Cheng Chen, Chenglei Gu, Jichao Chen
Topics & Concepts
ChemistryCancerComputational biologyDrugMicrotubuleDrug discoveryDrug resistanceDrug developmentTubulinAnticancer drugCancer therapyCarcinogenCancer researchCancer drugsProtein–protein interactionStructure–activity relationshipCancer treatmentMicrotubule polymerizationPharmacologyMechanism (biology)Cancer cellBiochemistrySmall moleculeCancer Research and TreatmentsClick Chemistry and ApplicationsUbiquitin and proteasome pathways