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Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics

Christopher H. Hulton, Emily A. Costa, Nisargbhai Shah, Àlvaro Quintanal-Villalonga, Glenn Heller, Elisa de Stanchina, Charles M. Rudin, John T. Poirier

2020Nature Cancer54 citationsDOIOpen Access PDF

Topics & Concepts

CRISPRGenome editingCas9Computational biologyBiologyFunctional genomicsGeneGenomeGenomicsGene targetingGeneticsCRISPR and Genetic EngineeringVirus-based gene therapy researchPluripotent Stem Cells Research
Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics | Litcius