IL-8 exacerbates CCl4-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway
Yuchen Ma, Yanni Bao, Lifang Wu, Yijun Ke, Lina Tan, Huan Ren, Jue Song, Qian Zhang, Yong Jin
Topics & Concepts
Hepatic stellate cellPI3K/AKT/mTOR pathwayFibrosisCCL4Hepatic fibrosisProtein kinase BExtracellular matrixCancer researchLiver injuryChemokineImmunologyMedicineInflammationBiologySignal transductionPathologyCarbon tetrachlorideChemistryInternal medicineCell biologyOrganic chemistryLiver physiology and pathologyLiver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and Disease